Five Fast Facts: Tesamorelin

Your Saturday morning peptide primer - everything you need to know in five quick points.

What It Is

Tesamorelin is a growth hormone-releasing hormone (GHRH) analogue specifically designed to target visceral abdominal fat. This dangerous fat accumulates around your organs. Unlike general fat loss compounds, Tesamorelin has a unique mechanism that preferentially mobilises deep abdominal fat whilst stimulating natural growth hormone production. Originally developed to address lipodystrophy, it's become highly valued for its ability to reduce stubborn belly fat that resists traditional weight loss approaches, whilst providing comprehensive anti-aging benefits through enhanced growth hormone.

How It Works

Tesamorelin works by binding to GHRH receptors in your pituitary gland, triggering sustained pulses of increased natural growth hormone production. The elevated growth hormone specifically targets visceral adipose tissue, promoting the breakdown and mobilisation of deep abdominal fat through enhanced lipolysis. Unlike subcutaneous fat, which sits under the skin, visceral fat responds particularly well to growth hormone stimulation, making Tesamorelin uniquely effective for reducing abdominal fat associated with metabolic dysfunction, inflammation, and cardiovascular risk. The compound induces a sustained elevation in growth hormone without completely suppressing endogenous production.

What It Does

This peptide delivers targeted visceral fat reduction alongside comprehensive growth hormone benefits. Users report a significant decrease in abdominal circumference and waist size, particularly from deep visceral fat; improved metabolic health markers, including insulin sensitivity and lipid profiles; enhanced body composition with better muscle-to-fat ratios; increased energy and vitality from optimised growth hormone levels; and improved sleep quality and recovery. It's particularly effective for people with stubborn abdominal fat that persists despite overall weight loss, or those with metabolic syndrome markers associated with visceral fat accumulation.

How To Use It

Tesamorelin is administered via subcutaneous injection at 1-2mg once daily in the abdominal area. The compound comes as a lyophilised powder that's reconstituted with sterile water and stored in the refrigerator. Most users inject before bed to enhance overnight growth hormone release and fat mobilisation. However, it can be effective at any consistent time. The higher dosing compared to other GHRH analogues reflects its specific design for visceral fat reduction. Users typically continue for 3-6 months to achieve significant reductions in visceral fat and improvements in metabolism.

Who It's For

Tesamorelin is ideal for anyone specifically targeting stubborn abdominal fat and visceral adipose tissue. It's particularly valuable for people with significant belly fat despite being relatively lean elsewhere, those with metabolic syndrome markers like insulin resistance or elevated triglycerides, anyone concerned about visceral fat's health risks beyond aesthetics, or people over 40 experiencing age-related abdominal fat accumulation and declining growth hormone. It's the go-to choice when abdominal fat reduction is the primary goal rather than general weight loss.

The Bottom Line

Tesamorelin stands out as the most targeted solution for visceral abdominal fat reduction available. Its unique mechanism specifically addresses the dangerous fat around organs that contributes to metabolic dysfunction, inflammation, and cardiovascular risk. While it provides general growth hormone benefits, its primary value lies in the preferential mobilisation of deep belly fat that resists traditional fat-loss approaches. Clinical studies show average reductions of 15-20% in visceral adipose tissue over 6 months. For those specifically concerned about abdominal fat and its health implications, Tesamorelin offers unmatched targeted efficacy.

Ready to target visceral abdominal fat? Shop Tesamorelin at Fragment and discover what targeted growth hormone stimulation can achieve.