SLU-PP-332 for Metabolic Resistance: When Your Body Won't Respond
- Peter Young

- Jan 9
- 3 min read

You've done everything right. Caloric deficit calculated precisely. Protein intake is optimal. Training consistent. Sleep prioritised.
The scale doesn't move. Measurements stay identical. Energy stays low. Body composition remains frustratingly unchanged.
You've tried different approaches. Lower calories - nothing. More cardio - nothing. Changed macro splits - nothing. Your body refuses to respond to interventions that work for everyone else.
This isn't a lack of commitment. It's metabolic resistance preventing your body from responding to signals that should trigger fat loss.
SLU-PP-332 addresses the cellular metabolic dysfunction creating resistance.
What Metabolic Resistance Actually Is
Metabolic resistance is a physiological dysfunction where your body stops responding normally to caloric deficits, exercise, or interventions that should trigger fat loss.
Your metabolism has become rigid. Cellular energy production is inefficient. Fat oxidation pathways don't activate properly. Mitochondrial function is compromised. The cellular machinery that should respond to the deficit isn't responding to training.
You're doing everything correctly, but your body's cellular metabolic response is broken.
Why Bodies Become Resistant
Chronic dieting - repeated aggressive deficits teach your body to become hyperefficient at energy conservation.
Metabolic adaptation: your body downregulates energy expenditure far beyond what weight loss alone explains.
Mitochondrial dysfunction - declining mitochondrial efficiency reduces cellular energy production and fat oxidation capacity.
Cellular rigidity - metabolic flexibility disappears. Your body struggles to switch to fat burning.
The result: your body becomes metabolically stuck, refusing to respond.
Why Traditional Approaches Fail
"Eat less" - further suppressing already-slow metabolism whilst increasing hunger and adaptation.
"Move more" - adding stress to an already-stressed system, often triggering additional slowdown.
"Be more patient" - waiting for a response that won't come because cellular machinery is dysfunctional.
You're failing to respond because cellular metabolic pathways are broken.
How SLU-PP-332 Addresses Resistance
Mitochondrial efficiency restoration - improving cellular energy production compromised through chronic dieting or adaptation.
Enhanced fat oxidation pathways - activating cellular mechanisms that have become unresponsive.
Metabolic flexibility improvement - restoring the ability to efficiently switch between fuel sources.
Cellular energy optimisation - addressing fundamental energy production dysfunction, preventing metabolic response.
This addresses resistance at the cellular level - not by forcing further restriction.
The Restoration Timeline
Weeks 1-2: Initial cellular improvements. Energy levels often increase first.
Weeks 3-4: Metabolic flexibility begins returning. The body becomes more responsive to deficit conditions.
Weeks 4-8: Substantial improvements. Body composition finally begins changing despite unchanged effort.
Weeks 8-12: Comprehensive restoration. The body responds normally to the deficit and training again.
The Protocol
SLU-PP-332 comes as 250mcg capsules. Start with one capsule in the morning for 15-30 days to assess response.
Based on results, many users add a second capsule in the afternoon for enhanced support. Flexible dosing allows for finding the optimal level of support for individual dysfunction severity.
Take with or without food. No timing restrictions.
Real-World Results
The scale weight that hadn't budged in 6 months, despite aggressive deficit reduction, finally begins to move. Body composition that remained unchanged despite extreme restriction begins to improve. Energy that was chronically low returns to normal.
Most importantly, the body becomes responsive again. The effort you've been making finally produces results because cellular metabolism functions properly.
The Dietary Reality
SLU-PP-332 doesn't mean ignoring diet. But it often allows better results with fewer restrictions.
Many users find moderate deficits with metabolic support produce better results than the aggressive restriction they were attempting, whilst metabolically resistant.
Strategic Enhancement
SLU-PP-332 + Tirzepatide or Retatrutide - combining cellular restoration with appetite regulation.
SLU-PP-332 + CJC-1295 + Ipamorelin - adding growth hormone optimisation supporting restoration.
The Metabolic Reset
Metabolic resistance isn't permanent dysfunction. It's cellular metabolic pathways that have become unresponsive through chronic stress or aggressive dieting.
Restoring cellular function allows your body to respond normally to effort again.
Address metabolic resistance with SLU-PP-332 at Fragment and restore your body's ability to respond.
Sometimes the problem isn't your effort - it's that your body's cellular response is broken.

Tried this and its super convenient but also effective.